0 A.D.
I haven't truly liked a video game since Myth 2: Soulblighter - a work of genius brought to us by Bungie. It is undoubtedly their magnum opus.
Although probably still years from a full release, 0 A.D. by Wildfire Games shows promise. There's a short game play video here. On the other hand, I waited years for Spore only to have it ultimately ruined by EA Games. And I don't see any Dwarfs lobbing bombs, so it can't truly replace Myth. But, we'll see....